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KMID : 1100920200410050339
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Korean Journal of Family Medicine
2020 Volume.41 No. 5 p.339 ~ p.345
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Anti-fracture Efficacy of Monthly Risedronate Compared with That of Weekly Risedronate in Postmenopausal Korean Women with Osteoporosis: A Nationwide Cohort Study
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Cho Yong-Ho
Bae Kyung-Hyun
Lee Dong-Ryul
Lee Jung-Un
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Abstract
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Background: Intermittent dosing regimens for oral risedronate (once-monthly and once-weekly) were developed for patient convenience. While several studies have reported the anti-fracture efficacy of weekly dosing, few have assessed monthly dosing. The lower efficacy of monthly dosing has been previously suggested. The aim of this study was to compare the anti-fracture efficacy of monthly and weekly dosing.
Methods: We obtained information from the Korea National Health Insurance Service database from 2012 to 2017 of Korean women of ≥50 years of age who used weekly or monthly risedronate. We compared the time of occurrence of the first osteoporotic fracture after the first prescription of risedronate. Using a Cox proportional model, we assessed incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for fractures at any site, and the hip, vertebral, and non-vertebral sites between both regimens. Propensity score weighting was used to balance the treatment groups.
Results: The study populations were distributed according to dosing frequency (monthly, 27,329; weekly, 47,652). There was no significant difference in the incidence rate of new fractures in any site (IRR, 1.008; 95% CI,0.963?1.055; P=0.737), hip (IRR, 0.999; 95% CI, 0.769?1.298; P=0.996), vertebral (IRR, 0.962; 95% CI, 0.890?1.040; P=0.330), or non-vertebral (1.022; 95% CI, 0.968?1.078; P=0.439) sites between monthly and weekly risedronate.
Conclusion: The anti-fracture efficacy at any site and the examined individual sites was similar for the monthly and weekly risedronate regimens. Large-scale randomized controlled trials are required for confirmation.
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KEYWORD
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Bisphosphonate, Risedronic Acid, Osteoporosis, Fracture
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